All functions
|
addMethPropCol
|
Add column for proportion of methylation |
aggregateMethyl
|
Aggregate methylation data to get
a summary methylation profile for each region set |
data
|
A data.table with binned methylation data for the first part of
the "Applying MIRA to a Biological Question" vignette.
Has data for 3 Ewing samples and 3 muscle-related
samples (human skeletal myoblasts and other related
samples). It is the product of `aggregateMethyl`. |
data
|
A data.table with binned methylation data for the second part
of the "Applying MIRA to a Biological Question" vignette.
Has data for 12 Ewing samples and 12 muscle-related samples
(human skeletal myoblasts and other related
samples). It is the product of `aggregateMethyl`. |
binRegion
|
Divide region into similarly sized bins. |
BSBinAggregate
|
Bins regions and aggregates methylation data across the regions by bin |
BSreadBiSeq
|
Read in files from biseq meth caller |
bsseqToDataTable
|
Convert a BSseq object to data.table format for MIRA. |
data
|
A data.table with annotation for a bisulfite sample (name and sample type) |
data
|
A data.table with annotation data for the "Applying MIRA to a
Biological Question" vignette. Has annotation data (sampleName
and sampleType columns) for 24 Ewing samples and 24 muscle-related
samples (human skeletal myoblasts and other related samples). |
data
|
A data.table with artificial binned methylation data |
data
|
A data.table containing methylation data
(position, number methylated reads and number of reads total)
This object contains reduced
representation bisulfite sequencing data from the
GM06990 B-lymphoblastoid cell line that was generated by the ENCODE
project (GEO accession GSE27584, sample GSM980583).
Only a subset of the full data is used in this object and the
data was switched from hg19 to hg38. |
data
|
A BSseq object which has the top 20 rows of the BSseq object "BS.chr22"
which was included as built-in data in the bsseq package |
data
|
A GRanges object with a ranges corresponding to Nrf1 Chip-seq peaks
in the GM12878 B-lymphoblastoid cell line (GEO accession GSE31477,
sample GSM935309). Only a subset of the ranges are used in
this object and the regions were switched from hg19 to hg38. |
MIRA
|
Methylation-based Inference of Regulatory Activity (MIRA) |
MIRAScore
|
Get MIRA score for each sample/region set combination |
plotMIRAProfiles
|
Plot summary methylation profile |
plotMIRAScores
|
Plot MIRA scores and compare different conditions |
scoreDip
|
Score methylation profile based on its shape |
SummarizedExperimentToDataTable
|
Make MIRA-compatible data.tables using information
from SummarizedExperiment-based classes |